Lecce will face AC Milan in Serie A's Week 28 on Saturday, March 8, 2025, at the Via del Mare Stadium in Lecce, Italy. Milan is under pressure to secure an away victory if they want to keep their hopes of reaching the European spots alive. Currently, Milan sits in 9th place with 41 points, while Lecce is in 15th with 25 points, needing a win to steer clear of the relegation zone.

Milan has a strong historical record against Lecce, having lost only 2 out of their last 37 encounters in Serie A, with 22 wins and 13 draws. Lecce has managed just one home victory against Milan in Serie A, which occurred on April 1, 2006, when they won 1-0 under coach Roberto Rizzo. Notably, the Rossoneri have also made history at Lecce's home by coming back from a 3-0 deficit to win 4-3 on October 23, 2011, thanks to a hat-trick from Boateng and a goal from Yepes, after Lecce's first-half goals from Giacomazzi, Oddo, and Grossmüller.